Raid monitor wall imune plus#

HSP – Clinical and Diagnostic Findings Lab testing does not help make a diagnosis Although there are petechiae, no thrombocytopenia or coagulopathy Possible thrombocytosis, +/- inflammatory markers, elevated WBC Be concerned if you get an abnormal urine analysis or abnormal Bun and creatinine. HSP - Complications  Intermittent colicky abdominal pain before rash  Intussusception and gastrointestinal bleeding  Edema of eyes, scrotum, hands  Seizure, strokes, pulmonary hemorrhage  Glomerulonephritis with rare end stage renal disease HSP Arthritis Glomerular vasculitis Scrotal edema Edema Intussception with bowel necrosis Purpuric rash

Raid monitor wall imune plus#

HSP – Typical Clinical Presentation  Purpura/petechiae of lower limbs  Plus 1 of the following:  Arthritis (75%) or arthralgias  Abdominal pain –colicky (50-75%)  Histopathology with IgA deposits  Renal disease (20-60%: hematuria, proteinuria)  Lasts 3-4 weeks and 1/3 of children have at least 1 recurrence HSP - Pathophysiology What is known? Antigenic precipitant Immune complex deposition of IgA T regulatory cell dysfunction Immunofluorescence studies show IgA, C3, and fibrin deposition within the walls of involved vessels. HSP - Describe Leukocyotoclastic vasculitis  Variety of immune cells deposited in the small vessel wall  Immune complex deposition, autoantibodies and inflammatory mediators, adhesion molecules Henoch-Schonlein Purpura (HSP)-Epidemiology  Most common - 49 % of all ped vasculitis  Annual incidence is 22/100,000  Peak age of onset 4-6 years  Boys > girls  Caucasians > African-Americans  Seasons- winter and spring- supporting infectious triggers

Explain the treatment for Kawasaki disease. Describe the clinical and laboratory criteria used for diagnosing Kawasaki disease. Understand the classical presentation, potential complications and prognosis of Kawasaki disease. Describe what is known about the pathophysiology of Kawasaki disease. Outline the epidemiology of Kawasaki disease. Understand the potential complications and prognosis for Henoch-Schonlein purpura, including how the prognosis in adults an and children differs. Describe when treatment is indicated for Henoch Schonlein purpura. Describe the clinical and laboratory criteria used for diagnosing Henoch-Schonlein purpura. Describe the typical clinical presentation for Henoch-Schonlein purpura.

Understand what is known about the pathophysiology of Henoch-Schonlein purprua.

Outline the epidemiology of Henoch-Schonlein purpura. Learning Objectives PRIMARY OBJECTIVES:  Epidemiology  Pathophysiology  Typical disease presentation Clinical presentation and diagnostic criteria Complications and prognosis  Treatment KEY LEARNING POINTS: 1.

Presentation on theme: 'Common Childhood Vasculitides: Henoch Schonlein Purpura and Kawasaki Disease Sharon Bout-Tabaku, MD, MSc Assistant Professor of Pediatrics Nationwide Children’s.'- Presentation transcript:Ĭommon Childhood Vasculitides: Henoch Schonlein Purpura and Kawasaki Disease Sharon Bout-Tabaku, MD, MSc Assistant Professor of Pediatrics Nationwide Children’s Hospital